The Treatment of Lyme Disease with Bee Venom
The following microorganisms
have to be considered when making the diagnosis of "New Lyme
by Dietrich K.
Klinghardt, M.D., Ph.D.
Lyme disease has
become, after AIDS, probably the fastest spreading infectious
disease. "Classical" Lyme disease is a bacterial infection caused
by a spirochete, Borrelia burgdorferi, which is passed to the patient
by a tick bite. Since several other infections that cause similar
symptoms can be transmitted by the same tick bite, and other
infectious agents not transmitted by a tick can cause similar
symptoms, the term "New Lyme Disease" is used by most holistic
physicians. Lyme disease is not only a frequent underlying causal
factor in chronic human illness, but also extremely common in pets,
especially in dogs and horses.
microti (a protozoan intracellular invader);
pneumoniae (associated with MS, ALS, Chronic Fatigue and
The following symptoms can
be caused by Lyme disease:
Fatigue (more severe in the early afternoon);
infections in the jaw bone, devitalized teeth, dental pain;
pains (especially in the spine);
nerve: Bell's palsy (60% are caused by Lyme disease, 30% by one
of six common viruses from the herpes family, such as EBV, Herpes
simplex type I, type II, type 6 etc);
nerve: sense of vibration in the face, TMJ and facial pain,
headache, tension and cramps in the face/skull/jaw;
(VII, VIII): tinnitus, vertigo, and hypersensitivity to noise;
(II, III, IV, VI): decreasing and changing eye sight (fluctuates
during the day), light sensitivity, floaters;
(X), Glossopharyngeal nerve (IX) and Hypoglossus (XII): difficulty
swallowing, faulty swallowing, reflux, hiatus hernia, heart
palpitations, supraventricular arrythmias.
epileptic seizures, insomnia, tremor, ataxia, movement disorders
irritability (key symptom in children), depression, bi-phasic
behaviour (manic-depression), bouts of anger, listlessness;
confusion, difficulty thinking, poor short term memory,
increasingly messy household and desk, difficulty finding the right
word, feeling of "information overload;"
pictures: can resemble or imitate any known psychiatric illness.
nervous system problems:
burning, vibration, numbness, shooting pains.
interstitial cystitis, prostatitis, sexual dysfunction, loss of
libido, pelvic pain, menstrual disorders.
system failure: with all known secondary illnesses such as herpes
virus infection, intestinal parasites, malaise.
General symptoms: hair
loss, loss of zest for life, sensitivity to electric appliances.
Until recently laboratory testing has been unsatisfactory
with a detection rate of probably below 30%. In the past it was
believed the laboratory evaluation of the spinal fluid was a reliable
way to confirm or refute the diagnosis of Lyme disease. This has been
proven wrong. The test with the broadest detection rate, the Western
Blot ELISA test, has low specificity. The test with the highest
specificity but with a fairly low detection rate was the PCR test.
The B. burgdorferi is a master at evading the body's immune system
and evading laboratory detection by modulating and changing its
surface antigens. It can form a cystic stage, which is resistant to
antibiotics, evades laboratory detection, and gives birth to healthy
spirochetes once the antibiotics are discontinued.
A new test
has become available recently: the C6 Lyme Peptide ELISA test (BBI
Clinical Laboratories, Tel.: 1-800-866-6254 or 860-225-1900, test
code: 556 - C6LPE. The test is based on the discovery of six
peptides on the surface of the spirochete, which are consistently
present and do not evade detection by the laboratory as many of the
other surface antigens of B. burgdorferi do. This test detects all B.
burgdorferi strains and genospecies. It is highly specific and more
sensitive than conventional tests for chronic Lyme disease. It is
also sensitive in early Lyme disease (which used to be problematic)
and can be used for accurate antibody results for Lyme vaccinated
Treatment has often been
unsatisfactory in spite of correct diagnosis. Multiple antibiotic
regimes have been tried with varying successes. The cystic stage
responds only to one antibiotic: metronidazole (Flagyl). This drug
should be given intravenously. The oral version is less effective and
hard on the liver. It should always be given together with the herb
"milk thistle" because of its liver-protective effect. A less
toxic alternative is tinidazole, a Flagyl-derivative that is
available in compounding pharmacies.
I use proteolytic
enzymes for the purpose of breaking up the cyst wall and making the
dormant form of B. burgdorferi inside the cyst vulnerable to both the
host's immune system and the medications given for treatment.
Dosage: Wobenzyme, 8-10 tablets three times/day between meals
and first thing a.m.
Treatment protocols using antibiotics
are outlined in the website of J. Borrescano, MD: www.lymenet.com. I
use, in selected cases, a combination of azithromycin or
clarithromycin 250-500 mg two times/day in combination with
trimethoprim 100 mg twice/day for 6-8 weeks.
treatment is a combination of enzymes, herbs, specific transfer
factors and the injection of honeybee venom.
follow the recommendations of Dr. Zhang, MD, LAc of New York
(http://www.dr-zhang.com). His special garlic extract with a high
concentration of Allicin:
2 mg Allicin/kg of bodyweight per
day for 6 months; HH (Houttuyniae Herba): 3 tablets three times/day
for 6 months.
His special Artemesia (wormwood) combination:
1-2 tablets three times/day for 6 months (usually recommended when
Babesia is involved).
In addition I use the specific herbal
combinations from the Monastery of Herbs in Los Angeles (Tel.:
818-360-4871). These are very effective 18-day programs. I use
Autonomic Response Testing to determine the most effective
combination. I rotate different regimes over the 6-month treatment
Specific Transfer Factors
When a pregnant cow is
infected with a certain illness, her first milk (colostrum) after the
calf is born contains specific peptides that prevent the illness in
the calf. Based on this principle, specific transfer factors have
become available for the treatment of B. burgdorferi, Babesia,
Mycoplasma pneumoniae etc. Most readily available are oral capsules
with dried peptide extracts (Chisolm Biological Laboratory, Tel.:
803-663 9618 / ext. 9777). By adding the specific transfer factors
into the treatment regime, the success rate can be dramatically
The pain relieving effect of bee
venom in the treatment of clinical conditions similar to Lyme disease
has been established a long time ago. Bee venom contains a number of
potent peptides which are responsible for its healing effect ("Bee
Venom Therapy for Chronic Pain," Dietrich Klinghardt, J. of Neurol
and Orthop. Med and Surg., Vol. 11, Issue 9, Oct 1990, pp. 195-197).
Recent research proved that one of the peptides in bee venom,
melittin, has a strong inhibitory effect on the Lyme spirochete at
very low doses ("Bee Stings as Lyme Inhibitor" by L. L. Lubke and
C. F. Garon, J. Clin. Infect. Diseases, July 1997, 25 Suppl. 1, pp.
48-51). When the spirochete is inhibited it does not multiply and is
vulnerable to the host's own immune system and to medication.
dosage and frequency of treatment is determined by the patient's
clinical response. Patients with Babesia or Mycoplasma infections
require higher dosages then those with only B. burgdorferi
Different bee venoms are on the market. I use the
product VeneX, which comes in two different strengths: VeneX-10 and
VeneX-20 (Table 1.). VeneX-20 is twice as concentrated as VeneX-10.
VeneX-10 contains 1.0 mg of bee venom per 1.0 ml. A 0.1 ml of this
solution delivers approximately the same amount of bee venom as a
natural bee sting. The content of melittin in bee venom is dependent
on where it is collected on the hive; the season and the pollen
source the bees have access to at the time. Generally between one
third and one half of the venom is melittin. Because of these
variables the symptoms seen on administration of the venom can also
vary. Bee venom is used for desensitization and is approved with the
FDA for this purpose. There is an official monograph in the
Homeopathic Pharmacopoea of the United States (HPUS), also recognized
by the FDA.
Table 1. Comparison of Venom Solutions.
* Dried Venom Sac
Equivalent (DVSE): 0.1 mg bee venom
The average maintenance
dosage is 1.0 ml of VeneX-10 (or 0.5 ml of VeneX-20) mixed with 2.0
ml preservative free buffered procaine (available from ApotheCure in
Dallas, TX) injected subcutaneously, given between one and three
times weekly for 6-12 months. Even though much of the venom's
effect is systemic, independent of the location where it is given,
additional benefits are observed by injecting the venom in specific
These areas include:
tender areas in the body, transition areas in the body, where soft
tissue meets bone, the occipital nuchal line, above and below the
zygoma, around the mastoid and jaw bone, the para-sternal area, the
spinous processes of the vertebrae;
kidney and adrenal area (often palpation reveals significantly
thymus (upper end of the sternum);
joints (in the most tender areas);
points (Bladder 23 for stimulating the adrenals, Gallbladder 1 to
improve Lyme related problems with vision, Bladder 10 and
Gallbladder 20 to stimulate melittin uptake into the brainstem
(cranial nerve problems), Kidney 3 to improve Lyme related kidney
therapy points: over the mastoid to improve Lyme related hearing and
balance problems (for more information on Neural Therapy: call
American Academy of Neural Therapy, Inc., at 206- 749 9967);
the vagus nerve: to treat Lyme related dental and jaw problems
(infected jaw bone, cavitations, Lyme related chronic
to treat Lyme related bladder problems, pelvic/prostate/sexual
the 2.5-3.0 ml bee venom and procaine mix over 10 areas, using 0.25
ml to 0.3 ml per injection. The injection is given with a 30g needle. The needle is advanced just deep enough for the needle
tip to barely reach beyond the sensory skin nerves. If it burns, the
needle is not deep enough. If it never burns, most likely the
injections are given too deep, where the medication will be quickly
flushed away by the blood stream and lymphatics, without having the
much-desired local effect. For a long needle this means
that the needle is inserted into the skin less than half way.
injections should be painless and well tolerated. There is a welling
up, itchiness and aching after 10 minutes or so, which becomes less
with an increasing number of treatments. The discomfort may increase
during the first four or five treatments and then lessen over time.
The initial response determines the treatment frequency. The first
injection often triggers an increase in well being and a decrease of
pain levels after a few hours; sometimes as late as 24 hours after
the injection. The initial improvement may last between 12 hours and
several days. This determines if the patient needs to be treated once
a day or as little as once a week. If the improvement is less than
desired a higher dose of bee venom may be needed.
with a low initial dose of 0.3 ml VeneX-10 or 0.15 ml VeneX-20 to
ride out the often strong initial reactions. Over the next treatments
I increase the dose, depending on the response, rather rapidly to the
full treatment dose (Table 2. and Table 3.). It is wise to wait with
injecting around the head until the patient no longer has strong
local reactions (redness, swelling).
Table 2. VeneX-10 and
Procaine Calculation Table.
3 x 0.3
5 x 0.3
7 x 0.3
Venom Sac Equivalent (DVSE): 0.1 mg bee venom
VeneX-20 and Procaine Calculation Table.
Dried Venom Sac Equivalent (DVSE): 0.1 mg bee venom
taught many patients to treat themselves with this procedure. It is
far less painful than the use of live bees. However, treatment with
live bees does not involve the use of technical supplies and is often
the only practical alternative.
If live bees are used I
recommend reading the textbook by Charles Mraz and the other
literature supplied by Apitronic Services (Tel.: 604-271-9414). I
also recommend using the Multi Treatment Mesh (MTM) or SoftSting
devices by the same company that allows the bee to not loose its
stinger, survive the procedure and return to its hive.
Everyone who uses bee venom on domestic animals or humans must have
an Anakit, Epipen or other medically approved "bee-sting kit,"
within immediate reach. The Anakit contains a pre-drawn syringe with
epinephrine, an oral antihistamine and instruction sheet. The Epipen
contains epinephrine in a self-injecting form.
should the patient experience a systemic reaction (usually within
minutes) with airway restriction, I recommend to inject one third
(1/3rd) of the epinephrine subcutaneously into the palmar (soft) side
of the forearm (same depth as the bee venom injection). The wheezing
will stop at the price of an agitated feeling in the patient. Now
he/she should take the antihistamine (swallow the pill), which takes
15-20 minutes to work. During this time, a second injection with
epinephrine may be needed. In 20 years of using bee venom, I never
needed to use this procedure. However, I have always combined bee
venom with procaine, which prevents most allergic reactions.
Clinical observations: many cases of chronic fatigue, MS,
ALS, memory loss, jaw problems, etc. are really undiagnosed Lyme
disease. With the new Lyme laboratory test many of these cases can be
appropriately diagnosed. The treatment outlined here is in my
experience very gentle and yet the most successful approach.
Acupuncture charts -- Apitronic Services, Tel.:
Dried peptide extracts -- Chisolm Biological
Laboratory, Tel.: 803-663-9618 / ext. 9777
Herbs -- Monastery
of Herbs, Los Angeles, Tel.: 818-360 4871
Herbs protocol --
Dr. Zhang, MD, LAc of New York, web site: www.dr-zhang.com
Lab test -- C6 Lyme Peptide ELISA test -- BBI Clinical
Laboratories, test code: 556 - C6LPE, Tel.: 1-800-866-6254 or 860-225
Multi Treatment Mesh (MTM) or SoftSting -- Apitronic
Services, Tel.: 604-271-9414
Neural Therapy and Autonomic
Response Testing workshops and resources -- American Academy of
Neural Therapy, Inc., (AANT) 410 East Denny Way, Suite 18, Seattle,
WA, USA, Tel.: 206-749-9967, Fax: 206-723-1367, E-mail:
Procaine (preservative free) -- ApotheCure
Pharmacy, Tel.: 1-800-969-6601
VeneX-10 and VeneX-20 -- Tel.:
RESOURCES FOR INFORMATION
Beck, B. F., MD (1997) The Bible of Bee Venom
Therapy. Health Resources Press, Inc., Silver Spring, MD, USA, book,
ISBN 1-890708-03, pp. 238. Reprint of the original 1935 edition of
Dr. Beck: Bee Venom Therapy - Bee Venom, Its Nature, and Its effect
on Arthritic and Rheumatoid Conditions. (available from Apitronic
Services: Tel.: 604-271-9414)
Broadman, J., MD (1997) Bee
Venom - The Natural Curative for Arthritis and Rheumatism. Health
Resources Press, Silver Spring, MD, USA, book, ISBN 1-890708-01-3,
references, index, glossary, foreword by Harold Goodman, DO, pp. 224
(available from Apitronic Services: Tel.: 604-271-9414)
D. K., MD (1990) Bee Venom Therapy for Chronic Pain. The Journal of
Neurological & Orthopedic Medicine & Surgery, Vol. 11, No. 3,
Klinghardt, Dietrich, MD (1999) Treatment
Protocol for Bee Venom Therapy. Apitherapy Education Service -
Apitronic Services, Richmond, BC, Canada, booklet, 11 pp.
L. L. and Garon, C. F. (1997) Bee Stings as Lyme Inhibitor. J. Clin.
Infect. Diseases, July, 25 Suppl. 1, pp. 48-51
Rick, ND and Klinghardt, Dietrich, MD (1999) Methodology for
Injectable Bee Venom Therapy. Apitherapy Education Service -
Apitronic Services, Richmond, BC Canada, 12 pp.
(1994) Health and the Honeybee. Queen City Publications, Burlington,
VT, USA, ISBN 0-9642485-0-6, pp. vii+92 (available from Apitronic
Services: Tel.: 604-271-9414)
Apitherapy Society, Inc., 5390 Grande Rd., Hillsboro, OH 45133 USA,
Tel.: 937-364-1108, Fax: (937) 364-9109, e-mail:
, web page: www.apitherapy.org/aas
American Academy of Neural Therapy, Inc., 410 East Denny Way,
Suite 18, Seattle, 98122 USA, Tel.: 206-749-9967, Fax: 206-723-1367,
, web page:
American Academy of Neural Therapy, Inc.
Venom Therapy Supplies and Books
Venom Therapy Supplies and Books Bee venom products and therapy
related books, literature and Apitherapy Education Service.
9611 No. 4 Road
Table 0.10 ml = 0.10 cc0.60 ml = 0.60 cc 0.20 ml = 0.20 cc0.70 ml =
0.70 cc 0.30 ml = 0.30 cc0.80 ml = 0.80 cc 0.40 ml = 0.40 cc0.90 ml =
0.90 cc 0.50 ml = 0.50 cc1.00 ml = 1.00 cc